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What is mazindol?

Mazindol is a sympathomimetic amine, which is similar to an amphetamine. It is also known as an “anorectic” or an “anorexigenic” drug. Mazindol stimulates the central nervous system (nerves and brain), which increases your heart rate and blood pressure and decreases your appetite.

Mazindol is used as a short-term supplement to diet and exercise in the treatment of obesity.

Mazindol may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about mazindol?
Use caution when driving, operating machinery, or performing other hazardous activities. Mazindol may cause dizziness, blurred vision, or restlessness, and it may hide the symptoms of extreme tiredness. If you experience these effects, avoid hazardous activities.

Mazindol is habit forming. You can become physically and psychologically dependent on this medication, and withdrawal effects may occur if you stop taking it suddenly after several weeks of continuous use. Talk to your doctor about stopping this medication gradually.

Who should not take mazindol?
You cannot take mazindol if you

have heart disease or high blood pressure;

have arteriosclerosis (hardening of the arteries);

have glaucoma;

have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), tranylcypromine (Parnate), or phenelzine (Nardil) in the last 14 days; or

have a history of drug or alcohol abuse.

Before taking this medication, tell your doctor if you have

problems with your thyroid;

an anxiety disorder;

epilepsy or another seizure disorder; or

diabetes.

You may not be able to take mazindol, or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above.

It is not known whether mazindol will harm an unborn baby. Do not take mazindol without first talking to your doctor if you are pregnant.

It is also not known whether mazindol passes into breast milk. Do not take mazindol without first talking to your doctor if you are breast-feeding a baby.

How should I take mazindol?
Take mazindol exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water.

Mazindol is usually taken one to three times a day before meals. Mazindol can be taken with food if it upsets your stomach. Follow your doctor’s instructions.

Never take more of this medication than is prescribed for you. Too much mazindol could be very dangerous to your health.

Store mazindol at room temperature away from moisture and heat.

What happens if I miss a dose?
Take the missed dose as soon as you remember. However, if it is almost time for your next dose or if it is already evening, skip the missed dose and take only your next regularly scheduled dose. A dose taken too late in the day will cause insomnia. Do not take a double dose of this medication.

What happens if I overdose?
Seek emergency medical attention.

Symptoms of a mazindol overdose include restlessness, tremor, rapid breathing, confusion, hallucinations, panic, aggressiveness, nausea, vomiting, diarrhea, an irregular heartbeat, and seizures.

Related/similar drugs
Zepbound, Wegovy, Mounjaro, semaglutide, phentermine, Saxenda, Alli

What should I avoid while taking mazindol?
Use caution when driving, operating machinery, or performing other hazardous activities. Mazindol may cause dizziness, blurred vision, or restlessness, and it may hide the symptoms of extreme tiredness. If you experience these effects, avoid hazardous activities.

Mazindol side effects

If you experience any of the following serious side effects, stop taking mazindol and seek emergency medical attention:

an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);

an irregular heartbeat or very high blood pressure (severe headache, blurred vision); or

hallucinations, abnormal behavior, or confusion.