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Is botulinum toxin a modern way of preserving youth or a dreadful poison? The history of botulinum toxin goes back to the XIX-th century, when Clostridium botulinum, the bacteria that produces botulinum toxin has been discovered. The first publications about this substance were not that positive as it is one of the most effective and fast-acting poisons on Earth.
Soon, with the help of multiple studies, from life-threatening substances, it turned into №1 medications for therapeutic and cosmetic purposes under the brand name Botox.
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Miracle Toxin: the Path from Poison to Medicine
Botulinum toxin used as a base for Botox is a neurotoxin produced by Clostridium botulinum. It is known to have a temporary paralyzing effect, blocking the nerve signals responsible for the muscles contractions.
Injections of botulinum toxin lead to a decrease in the perception of muscle stretch receptors and efferent activity of alpha and gamma motor neurons (clinically, this is manifested by pronounced muscle relaxation at the injection site and a significant decrease in pain).
At the present time, there 3 types of botulinum toxin approved for medical usage:P botulinum toxin type A (2 types) and botulinum toxin type B. Allergan, the manufacturer of Botox, uses for its preparation botulinum toxin type A.
Long History: how Botox Became the Number 1 Brand?
At the beginning of the XIXth century, there were described the first outbreaks of botulism among the population of Europe. In 1897, professor ща bacteriology Emil Van Ermengem had discovered that the reason for poisoning was a specific toxin produced by the cluster of bacteria later named Clostridium botulinum.
In the middle of the XXth century, Karl Laman and Edward J. Schantz have purified the toxin and made it suitable for clinical trials. In 1979, the American Food and Drugs Administration (FDA) approved for testing of botulinum toxin on humans.
After a few years, the preparation Oculinum Allergan (later named Botox) has officially received FDA approval for treating blepharospasm, autonomic disorders, hyperhidrosis, migraine, and spasticity. In 2002, FDA approved using Botox botulinum toxin products for cosmetic purposes – eliminating mimic facial lines on the forehead and around the eyes that has become a great breakthrough in cosmetology.
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Why Botox has no analogs when speaking about facial rejuvenation? Correction of Botox muscle relaxant takes the 1st place in the cabinets of thousands of cosmetologists and dermatologists worldwide, despite the great number of existing preparations and methods like lasers, mesotherapy, and dermal fillers on the market of aesthetic medicine.
The key answer lies in the botulinum toxin effects compared to other substances like hyaluronic acid. While sodium hyaluronate fills in the hollow areas in the derma, it is helpless in preventing the further development of the skin creases.
Botox injections do not have a volumizing effect, but they help to relax the muscles, decreasing the tension in the dermal tissues. Proteins of botulinum toxins block the nerve endings of the muscles, preventing them from receiving signals from the brain.
In such a way, shots of Botox are suitable for eliminating only the dynamic wrinkles caused by active facial expressions in the perioral and periorbital areas, on the forehead, and between the eyebrows. The action of Botox has a gradual effect, which will not even be noticeable in the first few days after the procedure. The 1st changes will appear at the end of the 1st week after the treatment with the peak of action at the end of 2nd month after the injection. After that, the effect of the toxin will start to weaken, fully disappearing after 4-6 months.
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The king of quality: safety comes first
Being one of the most in-demand products both for cosmetic and therapeutic purposes, there is an increased risk of being a fake. That is why the company Allergan, taking care of its clients, has elaborated a special package label, which is provided with a holographic coating in the form of the Allergan inscription.
Moreover, each pack contains 2 additional stickers, which the doctor can remove and stick to the patient’s record. These stickers should compulsorily contain the following information: trade name of a medicinal product, number of active units, batch number, and expiration date. Once you remove the stickers from the bottle with Botox, underneath, you will see the inscription “USED”.
All Botox products are checked up with the help of cell analysis in vitro that helps to exclude animal testing.
The cell analysis is a more precise and reliable method of quality control compared to the previously used methods. It is an incredible breakthrough in the manufacturing of Botox and other botulinum toxin products.
Knowing this information, you can buy Botox online safely. Choose carefully your supplier of botulinum neurotoxin products. Dermal Filler supply provides only top-quality 100% authentic medications from the world’s best manufacturers and brands
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